The autophagy thing

Hi peeps, I see a repeated claim both in the subs wiki sidebar as well as in comments shared in a lot of the posts here that one of the big great benefit from fasting is that autophagy is turned on. The sidebar wiki even suggest that detection of energy will turn it off. Where have this claim originated from? Autophagy is a constant process, pretty much every single cell in our body is constantly self eating. Its predominantly regulated through the different pathways between selective, and nonselective autophagy, as well as extracellular signaling in response to various endocrinal and stress related signals and triggers. The rates of these processes are truly astonishing. A typical cell will go through 30% of its plasma membrane in less than an hour, and it takes around 5-7 hours for a complete cell go-through. Yes, fasting will increase this somewhat, but not due to a need in repair. Caloric deficiency in an interaction between insulin and mTORC1/2 will increase the phagosomerate in a response to increase catabolic need. So, the reason fasting increases autophagy is because you start to rely on cellular contents for energy, so a general part of weightloss. The relatively minor increase in the phagosomerate would have very neglectable impacts on damage repair. The cells have intracellular pathways that respond to registered damage in proteins, membrane or organelles etc, so the very existence of damage is by itself a major amplifier of autophagy. You can absolutely not turn autophagy off, and remain alive for very long, and I'd be seriously skeptical to any claim of health benefits from fasting DUE to autophagy. It goes against several fundaments of cell biology and such claim fall well under the concept of "Extraordinary claims require extraordinary evidence" or similar. Since I saw this concept claimed so often in the threads, including the downright absurd claim that not beeing energy deficient will turn autophagy off claimed in the subwiki, I wanted to start a discussion so we can sort out the woo-woo from the science. Misinformation is a plague in our society, and when I see people promote fasting to help in a large amount of different ailments all under the embrella of "Starting autophagy to trigger cell repair and make your body heal itself" I got worried. I have no problem accepting claims of benefits from fasting, I use it for increasing insulin sensitivity and weightloss personally as well as increasing my ability to not eat just because of cravings, but let the message come from a place of honesty and information and not something shared with the same level of skepticism that tabloids deploy when they write articles about the newest dietary fad. References: Molecular Biology of the Cell, Sixth Edition Pages 725-727, Chapter 13, Chapter 15 https://www.amazon.com/Molecular-Biology-Sixth-Bruce-Alberts/dp/0815345240 Autophagy in the Regulation of Tissue Differentiation and Homeostasis https://www.frontiersin.org/articles/10.3389/fcell.2020.602901/full Autophagy revisited: A conversation with Christian de Duve https://www.tandfonline.com/doi/abs/10.4161/auto.6398 Autophagy: Renovation of Cells and Tissues https://www.cell.com/cell/fulltext/S0092-8674(11)01276-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867411012761%3Fshowall%3Dtrue